The Department of Transportation (DOT) classifies infectious substances as Class 6, Division 6.2 materials. These are further divided into two categories: Category A, Infectious Substances and Category B, Biological Substances. Regulated medical waste may be classified as category A or B depending on the infectious agent. Patient specimens may be classified as Biological Substances, Category B or exempt depending on the health status of the patient. International shipments of non-infectious genetically modified organisms or micro-organisms (GMOs/GMMOs) are assigned to Class 9, Miscellaneous by the International Air Transport Association (IATA). For shipment purposes, all biological materials fall into one of the following categories:
Proper classification of biological materials is a crucial step in the transportation of biological materials. The category determines the packaging, labeling, and documentation requirements. The Division of Research Safety (DRS) has developed a Classification Guide for Infectious Substances to illustrate how to properly classify biological materials for shipment.
The DOT and the IATA require the highest level of training and certification for people handling Category A Infectious Substances due to the increase risk of infection if the package is compromised in transit. Certified training ensures that the shipper understands the strict packaging, labeling, and documentation requirements.
For University of Illinois principal investigators who need to ship material as Infectious Substances, Category A, contact the DRS at 217-333-2755 or via email to make arrangements for training.
The DRS has developed an on-line training on Transportation of Infectious Substances, Category B for shipping infectious substances that qualify as Category B material according to the requirements outlined by the DOT at 49 CFR 173.199, 172.700 and IATA 1.5 Dangerous Goods Regulations. This training covers how to classify biological materials, select proper shipping names, select approved packaging materials, mark and label packages, and complete all required documentation to ship the following biological materials:
All category B materials must be registered with the Institutional Biosafety Committee (IBC) except for regulated medical waste shipped exclusively through Stericycle.
Before shipping any Category B biological substance or GMOs/GMMOs internationally, personnel must complete certified training.
University of Illinois Urbana-Champaign employees and students can be certified at no charge by completing the following two DRS online training modules:
Certified training is valid for two years, after which time the training modules must be repeated if shipping is to continue.
Laboratory personnel transporting biological material between buildings must follow the procedure below to ensure that the materials are contained in a way that will prevent release to the environment:
Unregulated or exempted biological materials may be transported either on campus or to off-site research locations for university business in a personal or university vehicle if they meet all packaging and labeling training requirements and the personnel transporting them are properly training. However, insurance companies may not cover an accident where hazardous materials were transported in a personal vehicle.
For materials that qualify for transport in a personal or university vehicles, the following precautions should be followed:
Materials meeting the definition of Category B biological substances may only be transported by personal or university vehicle if they are packaged and labeled according to DOT 173.199 and PI 650 and the driver has received proper training (certified to ship/transport category B material).
Transport of Category A material by personal vehicle is prohibited.
All biological materials must be packaged according to a triple packaging system. The three components of a triple packaging system are:
The primary receptacle holds the biological material and must be leak-proof or sift-proof. The closures should be secured with tape or parafilm to prevent them from opening due to vibration during transport. It is packed in the secondary container in such a way that, under normal conditions of transport, it will not break, be punctured, or leak its contents into the secondary container. If there are multiple fragile primary receptacles, they must be individually wrapped or separated to prevent contact.
The secondary container is a durable, watertight, leak-proof container that encloses and protects the primary receptacle(s). Several cushioned primary receptacles may be placed in one secondary container. If the primary receptacle contains any liquid, the secondary container must contain enough absorbent material to absorb all of the fluid from the primary receptacle(s) in case of breakage.
The outer container is a rigid and durable container with one side that is at least 10 cm by 10 cm (or 4 inches by 4 inches) that houses the secondary container. The outer package should be properly marked and labeled. It should be able to withstand outside influences such as physical damage while in transit. An itemized list of package contents must be included between the outer and secondary container.
Transporting Infectious Substances Safely
Department of Transportation (DOT)
Hazardous Materials: Infectious Substances (49 CFR Parts 171 et al.)
World Health Organization (WHO)
Guidance on Regulations for the Transport of Infectious Substances 2019-2020