All biological materials should be packaged according to a triple packaging system. The three components of a triple packaging system are:

1. Primary receptacle,
2. Leak-proof secondary container,
3. Rigid outer container

The primary receptacle holds the biological material and should be leak-proof and watertight. It is packed in the secondary container in such a way that, under normal conditions of transport, it will not break, be punctured, or leak its contents into the secondary container. If there are multiple, fragile primary receptacles, they should be individually wrapped or separated to prevent contact during transport.

The secondary container is a durable, watertight, leak-proof container that encloses and protects the primary receptacle(s). Several cushioned primary receptacles may be placed in one secondary container. If the primary receptacle contains any liquid, the secondary container should contain enough absorbent material to absorb all of the fluid from the primary receptacle(s) in case of breakage.

The outer container is a rigid and durable container with one side that is at least 10 cm by 10 cm (or 4 inches by 4 inches) that houses the secondary container. The outer package shall be properly marked and labeled. It should be strong enough to resist physical damage while in transit. An itemized list of package contents should be included between the outer and secondary container.